Award
National Institute of General Medical Sciences 5R35GM142847-05
Models of collective migration that integrate single-cell polarity and mechanics
Recipient
Johns Hopkins University, Baltimore, MD
Award Amount
$393,347.00
Ceiling
$393,347.00
Awarded
September 09, 2025
Identifier
5R35GM142847-05
Development of computational models to study collective cell migration, focusing on cell geometry, mechanics, and signaling to understand cell-cell interactions and migration processes relevant to wound healing and development.
Description
This project aims to develop computational physical models of collective cell migration with realistic geometry, mechanics, and cell-cell signaling to study effects of cell geometry on cell-cell interactions and how myosin activity fluctuations and mechanotransduction regulate cell-cell rupture events. The models will link physical and molecular aspects of cell-cell collisions to large-scale migration, driving future research in development.