Award
National Institute of Diabetes and Digestive and Kidney Diseases 4R01DK137771-03
Epigenetic regulation of intestinal tuft cells
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$1,255,082.00
Ceiling
$1,255,082.00
Awarded
July 29, 2026
Identifier
4R01DK137771-03
A research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases to study epigenetic regulation of intestinal tuft cells influenced by microbiota metabolites, aiming to develop personalized therapies for intestinal diseases.
Description
This project aims to understand how tuft cell regulation is epigenetically controlled, potentially via microbiota-derived metabolites, to develop personalized therapies for intestinal diseases. It investigates how microbiota metabolites influence stem cell differentiation into tuft cells through epigenetic enzymes and identifies mechanisms by which the epigenetic landscape of stem cells modulates tuft cell development.