Award
National Institute of General Medical Sciences 1R35GM166295-01
A novel IDR-mediated interaction network linking chromatin state to RNA export
Recipient
Baylor College of Medicine, Houston, TX
Award Amount
$416,000.00
Ceiling
$416,000.00
Awarded
July 20, 2026
Identifier
1R35GM166295-01
The award supports research to uncover mechanisms linking chromatin state to RNA export via intrinsically disordered regions in RNA export proteins, using structural biology and related methods.
Description
This project aims to elucidate the structural basis and spatial regulation of RNA export machinery, employing advanced tools in structural biology, epigenomics, chemical biology, and microscopy. The research focuses on understanding how chromatin and transcriptional states influence RNA export and how the machinery is spatially regulated in the nucleus, particularly the role of intrinsically disordered regions (IDRs) in RNA export proteins.