Award
National Heart, Lung, and Blood Institute 1K08HL185919-01
Immuno-Metabolic Drivers of Chronic Rejection after Lung Transplant
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$169,140.00
Ceiling
$169,140.00
Awarded
June 23, 2026
Identifier
1K08HL185919-01
NIH grant awarded to Washington University for research on immuno-metabolic mechanisms driving chronic rejection after lung transplant, aiming to develop therapies to prevent rejection and improve survival.
Description
This project focuses on understanding the mechanisms driving chronic rejection, specifically bronchiolitis obliterans syndrome (BOS), in lung transplant patients. It involves establishing a mouse model with accelerated BOS development due to ATG16L1 deficiency in monocyte-derived antigen-presenting cells. Preliminary data suggest that ATG16L1-deficient cells undergo metabolic adaptation leading to increased glycolytic inflammatory responses. The research aims to determine if inhibiting glycolysis in these cells can prevent BOS, identify metabolic pathways involved, and assess the role of IL-1β inflammatory signaling.