Award
NIH Reporter #5R01AG085316-03
Identifying T cell determinants of heritable Frontotemporal dementia
Recipient
CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH, UNITED STATES
Award Amount
$584,649.00
Ceiling
$584,649.00
Awarded
March 26, 2026
Identifier
5R01AG085316-03
This NIH-funded research project aims to understand how T cell dysfunction contributes to Frontotemporal dementia caused by C9ORF72 mutation, exploring interactions with the gut microbiome and identifying therapeutic targets.
Description
A project to identify pathways within T cells that contribute to neural inflammation in mice with a C9ORF72 mutation, evaluating T cell fate and function in human carriers to reveal pathways important for neurodegeneration and potential diagnostic markers.