Award
National Institute of Allergy and Infectious Diseases 5R01AI172210-04
Biophysical parameters of self-reactive TCR engagement in T1D
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$666,153.00
Ceiling
$666,153.00
Awarded
January 30, 2026
Identifier
5R01AI172210-04
Research project investigating TCR biophysical parameters in autoimmune Type 1 Diabetes to understand T cell function and tolerance mechanisms.
Description
The project focuses on understanding the biophysical parameters of T cell receptor (TCR) interactions with self-antigens in the context of Type 1 Diabetes (T1D). It aims to elucidate how TCR force levels and bond lifetimes influence T cell function and autoimmunity, with a particular focus on regulatory T cells (Tregs) and effector T cells restricted by autoimmune MHC alleles.