Award
National Cancer Institute 1R01CA300715-01
Mitigating the Impact of Obesity on Endometrial Intraepithelial Neoplasia and Cancer with Incretin Mimetics
Recipient
University of North Carolina at Chapel Hill, Department of Obstetrics & Gynecology
Award Amount
$658,093.00
Ceiling
$658,093.00
Awarded
July 14, 2026
Identifier
1R01CA300715-01
This award funds a research project at the University of North Carolina at Chapel Hill to study the effects of pharmacotherapy and dietary interventions on obesity-related endometrial cancer, aiming to reduce tumor burden and improve metabolic health.
Description
The project aims to investigate interventions targeting weight loss in endometrial cancer (EC) patients, including pharmacotherapy with tirzepatide and retatrutide, and reduced calorie diet regimens such as intermittent energy restriction (IER). The hypothesis is that these interventions will have anti-obesity and anti-tumorigenic effects, improving the metabolic environment and tumor microenvironment, thereby reducing EC burden. The study involves pre-clinical mouse models and a clinical pre-operative window study in patients, assessing the effects of incretin therapies alone and combined with IER on tumor growth and metabolic markers.