Award
National Institute of Neurological Disorders and Stroke 5R01NS133205-02
Role of a gut microbiota metabolite indole lactate in myelin repair
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$498,573.00
Ceiling
$498,573.00
Awarded
May 12, 2026
Identifier
5R01NS133205-02
A NIH-funded research project investigating the role of the gut microbiota metabolite indole lactate in promoting myelin repair to develop new treatments for multiple sclerosis.
Description
This project aims to identify bacteria-derived metabolites that promote myelin repair, potentially leading to new treatments for multiple sclerosis. The research will test the metabolite indole lactate's ability to promote remyelination in vivo, understand its mechanisms, and evaluate its efficacy in aged models using innovative tools and knockout models.