Award
NIH Reporter #1R21AR087354-01
cGas-STING pathway based medical countermeasure for vesicant skin injury
Recipient
University of Alabama at Birmingham
Award Amount
$408,374.00
Ceiling
$408,374.00
Awarded
August 21, 2026
Identifier
1R21AR087354-01
This NIH-funded research project focuses on developing medical countermeasures targeting the cGAS-STING pathway to treat skin injuries caused by vesicant chemical agents like lewisite. The study involves murine models to evaluate small molecule inhibitors for potential therapeutic use, aiming to create effective antidotes for chemical-induced skin injuries.
Description
The project aims to develop mechanism-based medical countermeasures against highly toxic vesicant warfare agents, such as arsenicals and mustards. The focus is on understanding the role of the cGAS-STING pathway in skin injury caused by these chemicals and screening small molecule inhibitors to attenuate toxicity.