Award
National Institute of Allergy and Infectious Diseases 5R21AI182540-02
Characterizing the Plasmodium falciparum Apicomplexan amino acid transporter 2 and its proline transport capability
Recipient
Harvard University D/B/A Harvard School of Public Health
Award Amount
$240,643.00
Ceiling
$240,643.00
Awarded
July 23, 2026
Identifier
5R21AI182540-02
Research project funded by NIAID to study the PfApiAT2 protein's role in proline transport in malaria parasite Plasmodium falciparum, aiming to understand its function and impact on malaria transmission and drug resistance.
Description
The project focuses on the role of membrane transport proteins in resistance to anti-malarial drugs, specifically examining the function of PfApiAT2 in proline transport in Plasmodium falciparum. The research aims to characterize the transport capacity of PfApiAT2 using heterologous expression systems and radiolabeled proline, generate knockout parasites, and determine their role in mosquito transmission stages.