Award
National Institute of General Medical Sciences 5R01GM155335-03
Noncanonical roles of Bim in heat shock-induced cell death
Recipient
University of TX MD Anderson Cancer Center
Award Amount
$490,122.00
Ceiling
$490,122.00
Awarded
June 03, 2026
Identifier
5R01GM155335-03
Research grant awarded to study the role of Bim protein in heat shock-induced cell death mechanisms, aiming to understand cellular responses to heat stress and potential therapeutic targets.
Description
This research grant focuses on studying the noncanonical roles of the protein Bim in regulating lysosomal trafficking and positioning, influencing susceptibility to heat shock-induced cell death. The project aims to characterize Bim's role in lysosomal trafficking, permeabilization, and exocytosis during heat shock-induced cell death, with implications for understanding heat-related pathologies and potential therapeutic targets.