Eunice Kennedy Shriver National Institute of Child Health and Human Development 5P50HD119693-21

Resource Core - Barton

Award to University of Florida for a Resource Core supporting muscle function assessments in mouse models of muscular dystrophy, aiding therapeutic evaluations.

Description

Critical to the evaluation of potential therapeutics (pharmacological, gene, or cell therapies) are sensitive and repeatable physiological assessments of muscle function applied to mouse models of dystrophy. Therefore, we are proposing to continue a Resource Core that performs ex vivo, in situ, and whole animal assessments of muscle integrity and function. This core will support the needs of the projects within the Center and serve as a national resource for functional evaluation of therapies for muscular dystrophies. The core includes instrumentation for muscle physiological measurements, specialized equipment for hindlimb suspension, documented free wheel running, treadmill running, and storage of samples in –80°C and liquid nitrogen freezers. Collaboration with colleagues to assess whole animal respiratory function will complement ex vivo diaphragm assessment. This resource has provided a vital service to the muscular dystrophy research community.

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