Award
National Institute on Aging 5R56AG084730-02
Optimization of a potent and cell active CK2 chemical probe for Alzheimer's disease therapy
Recipient
University of North Carolina at Chapel Hill
Award Amount
$796,443.00
Ceiling
$796,443.00
Awarded
August 04, 2025
Identifier
5R56AG084730-02
NIH-funded research project to develop and optimize selective CK2 kinase inhibitors as chemical probes for Alzheimer's disease therapy, involving medicinal chemistry, in vivo validation, and stem cell assays.
Description
This project aims to create high-quality chemical tools to characterize the role of protein kinase CK2 in Alzheimer's disease pathology and confirm its potential as a therapeutic target. The work involves medicinal chemistry to optimize CK2 inhibitors for in vivo use, including improving blood-brain barrier penetration, and testing in stem cell assays and a mouse model of Alzheimer's disease.