Award
National Institute of Allergy and Infectious Diseases 5R21AI194022-02
Human normal tissue patient-derived organoids for pre-screening GI radiation countermeasure drugs
Recipient
Columbia University Health Sciences
Award Amount
$164,500.00
Ceiling
$164,500.00
Awarded
July 24, 2026
Identifier
5R21AI194022-02
This NIH-funded project develops human tissue-based organoid models to pre-screen GI radiation countermeasure drugs, focusing on efficacy and safety across different ages and sexes, aiming to improve treatment for acute radiation syndrome.
Description
The project aims to develop and validate the use of human normal tissue patient-derived organoids (NT-PDOs) from healthy normal small intestine biopsies for pre-screening new candidate gastrointestinal (GI) radiation countermeasures, assessing the significance of age and sex in a high-throughput multi-well format. It addresses the lack of FDA-approved medical countermeasures for GI acute radiation syndrome (ARS) and seeks to improve personalized approaches while reducing reliance on animal models.