Award
National Institute of General Medical Sciences 5R01GM127365-08
Structure and Function of Essential Nucleoprotein Complexes Along a Viral Genome Packaging Pathway
Recipient
University of Colorado Denver, Aurora, CO
Award Amount
$424,356.00
Ceiling
$424,356.00
Awarded
May 04, 2026
Identifier
5R01GM127365-08
Research project funded by NIGMS to study the final step of viral genome packaging in dsDNA viruses, aiming to understand the mechanisms of genome termination and motor recognition using various scientific approaches.
Description
The project investigates the mechanisms of genome packaging in large double-stranded DNA viruses, focusing on the final step of genome termination during packaging. Using biochemical, biophysical, single-molecule, and structural approaches, the study aims to elucidate how the translocating motor recognizes genome ends, senses DNA length, and how finishing proteins promote end maturation and terminase ejection. The research has broad implications for virology and cell biology, given the conservation of these processes across dsDNA viruses.