NIH Reporter #1K08AI197864-01A1

Deciphering interactions between human T cells and cardiomyocytes in immune checkpoint inhibitor-related myocarditis

This award funds a research project led by Steven Blum, MD at Massachusetts General Hospital to study immune checkpoint inhibitor-related myocarditis. The project focuses on understanding the role of T cells in myocarditis and developing therapeutic strategies to reduce this adverse event without affecting cancer treatment efficacy.

Description

Research project to determine the drivers of immune checkpoint inhibitor-related myocarditis (irMyocarditis) and therapeutically modulate interactions between T cells and cardiomyocytes using patient samples and model systems. The project aims to define cardiomyocyte-reactive T-cell clones, identify pathogenic interactions between T cells and non-immune cells, and test potential therapies in co-culture models to develop a clinical trial protocol to mitigate irMyocarditis in patients.

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