Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 4R00AR083486-02
Novel models to study dorsal root ganglion neurons in knee osteoarthritis pain
Recipient
University of Cincinnati
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
September 11, 2025
Identifier
4R00AR083486-02
The award supports research to develop novel models and therapeutic targets for knee osteoarthritis pain by studying dorsal root ganglion neurons, aiming to improve treatment options and reduce reliance on opioids.
Description
This project aims to identify dorsal root ganglion (DRG) populations driving knee osteoarthritis-induced neural circuit changes and explore therapeutic targets, focusing on TRPV1-expressing neurons. It involves profiling active DRG neurons using TRAP techniques, electrophysiology, behavioral assays, and co-culture systems with human tissue to develop novel analgesic strategies for knee osteoarthritis pain.