Award
NIH Reporter #5R01HL166518-04
Spatiotemporal regulation of polyploidy in zebrafish cardiac tissue regeneration
Recipient
Weill Medical College of Cornell University
Award Amount
$692,838.00
Ceiling
$692,838.00
Awarded
August 10, 2026
Identifier
5R01HL166518-04
This NIH-funded project studies how polyploidy affects heart tissue regeneration in zebrafish, aiming to uncover cellular mechanisms that could improve human heart repair therapies.
Description
The project investigates the role of polyploidy in epicardial regeneration, including mechanisms involving mechanical cues, Yap signaling, and novel pathways. The research aims to define signaling cascades, leader-follower cell interactions, and the functional significance of epicardial polyploidy in heart regeneration, with implications for tissue repair and disease treatment.