Award
National Institute on Aging 5U19AG073585-05
EFFECTS OF STRESS, ALLOSTATIC LOAD, AND THE EXPOSOME ON BRAIN STRUCTURE, FUNCTION, AND COGNITION IN THE EARLY-TO-MIDLIFE TRANSITION
Recipient
Washington University
Award Amount
$173,919.00
Ceiling
$173,919.00
Awarded
May 14, 2026
Identifier
5U19AG073585-05
This award funds research on how stress and biological aging impact brain health and cognition during early to mid-life, focusing on immune and social factors that contribute to dementia risk.
Description
The project aims to investigate stress across the adult lifespan and mechanisms of allostatic load and immune dysregulation affecting brain structure, function, and neurochemistry, thereby increasing brain vulnerability for cognitive decline and dementia in later life. The study focuses on the young adult to mid-life transition, examining immune dysregulation, inflammation, and social determinants of health, with a multidisciplinary approach involving neuroimaging, biomarkers, and social factors.