Award
National Institute of General Medical Sciences 2R35GM136239-06
Peptide Processing by Copper Enzymes
Recipient
Oregon Health & Science University
Award Amount
$619,006.00
Ceiling
$619,006.00
Awarded
March 19, 2026
Identifier
2R35GM136239-06
NIH awarded a grant to Oregon Health & Science University for research on copper-mediated peptide processing enzymes, focusing on their reaction chemistry and structural studies to advance understanding of peptide amidation and crosslinking relevant to therapeutic development.
Description
This NIH grant project aims to understand the reaction chemistry of copper-dependent peptide processing enzymes, specifically PHM (amidation) and AhyBURP (peptide crosslinking), which are important for producing biologically active mature peptides and have implications for antibacterial, antiviral, and anticancer therapeutics.