Award
National Institute of Allergy and Infectious Diseases 5R21AI169111-02
A novel c-di-AMP-based recombinant BCG vaccine
Recipient
Albany Medical College, Albany, NY
Award Amount
$203,750.00
Ceiling
$203,750.00
Awarded
February 01, 2024
Identifier
5R21AI169111-02
Development of a recombinant BCG vaccine secreting c-di-AMP to enhance immune response and protection against tuberculosis, aiming to improve vaccine efficacy and reduce TB incidence globally.
Description
This project aims to construct recombinant BCG strains that secrete c-di-AMP and induce IFN-I in the vaccinated host, potentially improving BCG's efficacy against tuberculosis. The research could lead to a more effective TB vaccine, significantly impacting public health by reducing TB incidence.