Award
NIH Reporter #5R01DK126728-05
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
Recipient
University of Minnesota, Minneapolis, MN
Award Amount
$639,978.00
Ceiling
$639,978.00
Awarded
December 18, 2024
Identifier
5R01DK126728-05
This award funds a study to evaluate long-term islet graft function and glycemic control in patients 5-20 years after total pancreatectomy with islet autotransplant, aiming to improve clinical care and diabetes management.
Description
Total pancreatectomy with islet autotransplant (TPIAT) is performed to treat severe, intractable pain of chronic pancreatitis. The study aims to evaluate long-term islet graft function, glycemic control, and diabetes complications in patients 5-20 years post-TPIAT. It will assess mechanisms affecting glycemic regulation, including incretin hormones and alpha cell dysregulation. The study will enroll at least 200 participants and use C-peptide levels from mixed meal tolerance testing as a marker of endogenous islet function. The research seeks to determine the proportion of patients maintaining islet graft function long-term and its impact on diabetes management.