Award
National Institute of General Medical Sciences 1R35GM160291-01
Development of Haloperoxidase Enzymes for New Applications in Chemical Synthesis
Recipient
Emory University
Award Amount
$2,021,315.00
Ceiling
$2,021,315.00
Awarded
August 05, 2025
Identifier
1R35GM160291-01
Award to Emory University for developing VHPO enzymes to improve selective halogenation in chemical synthesis, supporting drug discovery and sustainable pharmaceutical production.
Description
This project aims to expand the capabilities of vanadium-dependent haloperoxidase (VHPO) enzymes for chemical synthesis, including enzymatic halide recycling and defunctionalative halogenation, to facilitate drug discovery and broaden the synthetic repertoire. It focuses on developing VHPO enzymes as a biocatalyst platform for selective halogenation and transformations, enhancing the synthesis of biologically active compounds.