Award
National Institute of General Medical Sciences 1F32GM165088-01
Development of a Three-Component Iron-Catalyzed Difluoromethylation Reaction
Recipient
University of California Los Angeles
Award Amount
$75,880.00
Ceiling
$75,880.00
Awarded
May 20, 2026
Identifier
1F32GM165088-01
Award for developing a novel iron-catalyzed difluoromethylation reaction to create C(sp3)-CF2H bonds using innovative chemical strategies and advanced techniques, aiming to enhance sustainable synthesis methods.
Description
The project aims to develop a three-component iron-catalyzed difluoromethylation reaction to facilitate the formation of C(sp3)-CF2H bonds. It employs two strategies: using HCF2–X electrophiles as radical precursors and organozinc reagent [(DMPU)2Zn(CF2H)2] as a nucleophilic source. The research will utilize advanced spectroscopic techniques and computational chemistry to accelerate development. The long-term goal is to expand the use of earth-abundant iron in synthetic methods for high-value molecules.