Award
National Institute of Allergy and Infectious Diseases 5R01AI168302-04
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
Recipient
Vanderbilt University Medical Center
Award Amount
$489,526.00
Ceiling
$489,526.00
Awarded
August 06, 2025
Identifier
5R01AI168302-04
Research project funded by NIAID to study mechanisms by which Salmonella Typhimurium disrupts gut colonization resistance during infection, focusing on inflammation and metabolism.
Description
This project investigates how Salmonella enterica serovar Typhimurium (S. Tm) overcomes colonization resistance in the gut microbiota during infection. It focuses on the role of intestinal inflammation, propionate metabolism, and microbiota-derived aspartate in facilitating S. Tm expansion and virulence.