Award
National Heart, Lung, and Blood Institute 1K99HL181288-01
Decoding Nuclear Mechanosignaling and Epigenetic Mediators of Mechanical Memory in Cardiomyocytes
Recipient
University of Pennsylvania
Award Amount
$169,020.00
Ceiling
$169,020.00
Awarded
September 19, 2025
Identifier
1K99HL181288-01
NIH-funded research project awarded to University of Pennsylvania to study mechanical memory in cardiomyocytes and its molecular and epigenetic regulators, with potential therapeutic implications for heart disease.
Description
Research project focusing on the time-dependent nuclear responses to extracardiac stiffening in cardiomyocytes, including changes in chromatin architecture, gene expression, and DNA damage responses, aiming to identify molecular conduits and epigenetic regulators of mechanical memory and explore therapeutic interventions.