Award
National Heart, Lung, and Blood Institute 5R33HL165366-04
Randomized Control Trial of oxygen therapy in Children and Adolescents with Down Syndrome and Obstructive Sleep Apnea
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$4,125,108.00
Ceiling
$4,125,108.00
Awarded
September 06, 2025
Identifier
5R33HL165366-04
This award funds a clinical trial investigating oxygen therapy for children and adolescents with Down Syndrome suffering from obstructive sleep apnea, focusing on safety, efficacy, and improvements in cognitive and cardiac outcomes.
Description
A randomized trial to test the hypothesis that individuals with Down Syndrome and moderate to severe obstructive sleep apnea will have a safe and favorable response to low-flow oxygen treatment, aiming to improve neurocognition, cardiac function, sleep, and quality of life.