Award
National Cancer Institute 1R15CA274189-01A1
Finding NEMO's Switchable MRI Signal Using Microfluidic Tumor Models
Recipient
West Virginia University
Award Amount
$444,603.00
Ceiling
$444,603.00
Awarded
July 05, 2023
Identifier
1R15CA274189-01A1
Development of a novel MRI contrast agent targeting breast cancer cells to improve diagnosis accuracy and safety, evaluated in tumor models and mice.
Description
The project aims to develop a novel MRI contrast agent, NEMO particles, that respond to endosomal pH to generate contrast only inside breast cancer cells, providing a binary readout of benign or malignant. The project will evaluate the contrast in 3D microfluidic tumor models and in mice, assessing toxicity, specificity, and safety. The research will include creating a portable apparatus for MRI of microfluidic tumor models and training undergraduates in nanomaterials and medical imaging.