NIH Reporter #1R01HD116609-01A1

Mechanistic intersection between placental vascular and newborn neuronal development

This award supports research to investigate gene expression changes in the placenta linked to adverse neurodevelopmental outcomes in HIV-exposed but uninfected children, using advanced molecular and animal model techniques to understand the placenta-brain axis and optimize antiretroviral therapy during pregnancy.

Description

The project focuses on analyzing gene expression changes in the placenta associated with neurodevelopmental outcomes in children exposed to HIV. The research involves spatial transcriptomics, immunostaining, flow cytometry, and mouse models. The project aims to improve understanding of mechanisms affecting placental and fetal brain development in the context of maternal HIV and antiretroviral therapy.

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