National Cancer Institute 5R01CA273123-05

Investigating and modeling MYD88L265P and co-occurring mutations in mature B-cell malignancies

NIH grant awarded to Dana-Farber Cancer Institute to study MYD88L265P mutation and co-occurring genomic alterations in B-cell lymphomas, aiming to improve diagnosis and develop targeted therapies using mouse models.

Description

This NIH grant project aims to investigate the molecular mechanisms by which MYD88L265P mutation, Chr6q deletion, and other genomic alterations induce lymphomagenesis in B-cell lymphomas, with the goal of improving diagnosis, prognosis, and developing targeted therapies. The study involves generating transgenic mice to study the role of these mutations and develop preclinical models for testing therapies.

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