Award
National Institute of Dental and Craniofacial Research 4R01DE029951-02
Targeting Endosomal Receptors for Treatment of Chronic Pain
Recipient
New York University
Award Amount
$795,324.00
Ceiling
$795,324.00
Awarded
July 31, 2024
Identifier
4R01DE029951-02
Research project funded by NIH to develop nanoparticle technology targeting endosomal GPCRs in neurons to find new treatments for chronic pain.
Description
The proposed research aims to discover mechanisms of pain/nociceptive signaling and define drug targets, focusing on G protein-coupled receptors (GPCRs) and their redistribution to endosomes in neurons. The project will develop nanoparticles targeting neurons to study endosomal GPCR signaling, ion channel regulation, and validate eGPCRs as therapeutic targets for chronic pain conditions.