Award
NIH Reporter #5K08DK140618-02
The transcription factor RUNX1 is pivotal in TGFβ-activated cholangiocyte signaling with the immune system in biliary fibrosis
Recipient
Virginia Commonwealth University
Award Amount
$176,148.00
Ceiling
$176,148.00
Awarded
July 29, 2026
Identifier
5K08DK140618-02
The award supports research on the role of the transcription factor RUNX1 in cholangiocyte signaling activated by TGFβ, aiming to understand and develop therapies for biliary fibrosis associated with diseases like primary sclerosing cholangitis.
Description
This project investigates the mechanistic role of RUNX1 in TGFβ-stimulated fibroinflammatory effects and aims to identify cellular/molecular targets for developing novel therapeutic strategies for biliary fibrosis. The study focuses on diseases such as primary sclerosing cholangitis and primary biliary cholangitis, where biliary fibrosis is the predominant pathological process involving signaling among activated bile duct cholangiocytes, immune cells, and fibrosis-producing myofibroblasts.