Award
National Institute of General Medical Sciences 5P20GM121327-10
Regulation of one-carbon metabolism and purine synthesis by YRDC in hepatocellular carcinoma
Recipient
UNIVERSITY OF KENTUCKY
Award Amount
$234,292.00
Ceiling
$234,292.00
Awarded
January 30, 2026
Identifier
5P20GM121327-10
The award supports research on the role of YRDC in tumor metabolism and its potential as a therapeutic target in hepatocellular carcinoma, aiming to improve treatment outcomes.
Description
This project aims to elucidate how YRDC drives cellular growth and tumor metabolism in hepatocellular carcinoma (HCC), focusing on its role in activating one-carbon metabolism and purine synthesis. The study will explore mechanisms of YRDC upregulation, its regulation by KRAS and MAPK/ERK pathways, and assess the therapeutic potential of targeting YRDC to improve HCC treatment.