Award
National Institute of Allergy and Infectious Diseases 5R01AI187028-02
Increasing the protective capacity of antibodies by enhancing Fc-mediated responses
Recipient
University of Georgia, Athens, GA, United States
Award Amount
$416,276.00
Ceiling
$416,276.00
Awarded
May 04, 2026
Identifier
5R01AI187028-02
This NIH-funded project investigates how various factors modulate Fc-mediated antibody responses to enhance vaccine and antibody therapy efficacy against influenza and Streptococcus pneumoniae.
Description
The project aims to identify factors regulating immune responses to improve protection against influenza virus and Streptococcus pneumoniae using antibodies that require Fc-mediated functions. It focuses on understanding how epitope location, antibody glycosylation, oligomerization, and immune cell properties influence Fc-mediated immune responses such as ADCC, ADCP, and CDC.