Award
National Institute of Mental Health 5R01MH121608-05
Harnessing Hormonal Variation to Probe Neural Mechanisms and Optimize CBT Outcomes for OCD
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$685,169.00
Ceiling
$685,169.00
Awarded
June 27, 2025
Identifier
5R01MH121608-05
Research grant to study the impact of hormonal variation on neural mechanisms and optimize cognitive behavioral therapy outcomes for OCD, focusing on sex differences and menstrual cycle phases.
Description
This grant supports research on neural mechanisms of OCD and personalized treatment approaches based on hormonal status. The study examines whether delivering cognitive behavioral therapy involving exposure and ritual prevention (EX/RP) to women during high estrogen states improves extinction memory retention via engagement of the fear extinction brain network, leading to better clinical outcomes. It also explores sex differences in extinction processes.