Award
National Institute of General Medical Sciences 5P20GM125507-08
Optimizing open placebos for chronic pain patients
Recipient
Rhode Island Hospital, Providence, RI, United States
Award Amount
$91,647.00
Ceiling
$91,647.00
Awarded
September 02, 2025
Identifier
5P20GM125507-08
This NIH-funded project investigates the effectiveness of open-label placebos to reduce opioid use and pain in chronic pain patients, addressing the opioid epidemic by testing different rationale conditions in a randomized clinical trial.
Description
The project aims to examine the efficacy of open-label placebos (OLPs) in treating chronic pain among opioid-using patients. The study will compare four conditions: evidence-based rationale, mindfulness rationale, no rationale, and no treatment. Participants will take two placebos daily for 21 days, with remote assessments of opioid use and pain.