# NIH Reporter #5R01AI186995-02

Molecular characterization and modeling efficient antibody effector function

**Recipient:** Dartmouth College

**Award Amount:** $442,024.00
**Ceiling:** $442,024.00

**Awarded:** December 05, 2025

**Identifier:** 5R01AI186995-02

The project investigates how antigen, antibody, and effector-cell properties shape antibody effector functions, with the goal of developing quantitative models and design criteria for antibody therapeutics.

### Description

Research project to experimentally characterize antibody features that trigger potent antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, and to establish rules guiding antibody immunotherapies.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11248347)