Award
National Institute of Neurological Disorders and Stroke 1R21NS146792-01
Cholinergic regulation of epidermal neurons
Recipient
University of California, San Diego
Award Amount
$439,875.00
Ceiling
$439,875.00
Awarded
June 12, 2026
Identifier
1R21NS146792-01
NIH grant awarded to study how keratinocyte-derived acetylcholine affects sensory neuron growth, potentially impacting nerve regeneration and neurodegenerative diseases.
Description
This NIH-funded project aims to explore the role of keratinocyte-derived acetylcholine in regulating sensory neuron growth in the skin, with potential implications for nerve regeneration and neurodegenerative conditions. The project tests the hypothesis that keratinocyte-derived acetylcholine constrains sensory neuron growth via M1R, involving in vitro and in vivo studies using mouse models with conditional knockdown of choline acetyltransferase in keratinocytes.