Award
National Institute of Neurological Disorders and Stroke 5UH3NS132127-04
Single Molecule Detection of L1 Insertions and Intermediates
Recipient
Dana-Farber Cancer Institute
Award Amount
$698,829.00
Ceiling
$698,829.00
Awarded
March 24, 2026
Identifier
5UH3NS132127-04
Development of genomic tools and single-cell mapping approaches to detect and analyze LINE-1 (L1) retrotransposon insertions and intermediates, supporting the Somatic Mosaicism across Human Tissues Network.
Description
This project aims to develop new tools to assess the contributions of the LINE-1 (L1) retrotransposon to somatic mosaicism in normal human tissues. The research will enable genome-wide characterization of L1 insertions using long-read and single-cell technologies. The project will support the Somatic Mosaicism across Human Tissues (SMaHT) Network to create comprehensive catalogs of genetic variation.