Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK123078-05
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
Recipient
University of Florida
Award Amount
$322,080.00
Ceiling
$322,080.00
Awarded
July 18, 2024
Identifier
5R01DK123078-05
Research project funded by the National Institute of Diabetes and Digestive and Kidney Diseases to study how the circadian clock protein BMAL1 regulates kidney sodium channels and blood pressure, aiming to uncover mechanisms relevant to hypertension treatment.
Description
This project investigates the molecular mechanisms by which circadian proteins regulate sodium channels and blood pressure, with potential implications for hypertension therapeutics. The study focuses on the role of the circadian protein BMAL1 in regulating the epithelial sodium channel (ENaC) and MARCKS protein in the kidney, and their impact on blood pressure control.