Award
National Institute of General Medical Sciences 5R21GM155773-02
Improving the Sensitivity and Selectivity of Laser Desorption Ionization Using N-Heterocyclic Carbene Mass Ionization Tags
Recipient
University of Notre Dame, IN, United States
Award Amount
$194,699.00
Ceiling
$194,699.00
Awarded
July 23, 2025
Identifier
5R21GM155773-02
This NIH grant supports research to enhance mass spectrometry sensitivity and selectivity using N-heterocyclic carbene tags, potentially advancing disease biomarker discovery and proteomics.
Description
The project aims to develop a chemical platform employing N-heterocyclic carbenes and gold nanoparticles to improve peptide ionization efficiency, which is critical for elucidating protein structure. This increased sensitivity could reveal new disease biomarkers and provide a protein-level view of cellular functions.