Award
National Institute of Allergy and Infectious Diseases 1R21AI193666-01A1
Role of SLC46A3 in the pathogenesis of inflammatory bowel disease
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$251,250.00
Ceiling
$251,250.00
Awarded
April 22, 2026
Identifier
1R21AI193666-01A1
The award funds research to study the role of SLC46A3 in immune response and gut health related to Inflammatory Bowel Disease, focusing on NOD2 signaling and MDP transport.
Description
This project aims to investigate the role of the solute carrier transporter SLC46A3 in the interaction between gut microbiota and the innate immune system, specifically through NOD2 signaling. The study will examine the role of SLC46A3 in facilitating MDP transport and subsequent NOD2 activation, with implications for Inflammatory Bowel Disease (IBD).