Award
National Cancer Institute 5K99CA299410-02
Beyond Lysis: Deciphering the Role of Perforin-Mediated Ferroptosis in Anti-Tumor Immunity
Recipient
University of Michigan at Ann Arbor
Award Amount
$139,968.00
Ceiling
$139,968.00
Awarded
June 08, 2026
Identifier
5K99CA299410-02
NIH awarded a research grant to the University of Michigan to study perforin-mediated ferroptosis in tumor cells, aiming to improve cancer immunotherapy by elucidating the underlying mechanisms and metabolic regulators.
Description
This NIH research grant focuses on understanding how perforin induces ferroptosis in tumor cells to enhance anti-tumor immunity and develop novel cancer immunotherapies. The project aims to define molecular mechanisms, characterize the role in immunity, and determine tumor metabolism's impact on perforin-induced ferroptosis.