Award
National Institute of Allergy and Infectious Diseases 1P01AI194959-01
Project 2
Recipient
University of Colorado Denver, Aurora, CO, United States
Award Amount
$979,353.00
Ceiling
$979,353.00
Awarded
June 26, 2026
Identifier
1P01AI194959-01
This award funds a research project studying mucosal microbiome changes and immune responses related to rheumatoid arthritis, aiming to understand disease development and progression through longitudinal studies.
Description
The project aims to study mucosal alterations in the microbiome and chronic local inflammation related to rheumatoid arthritis (RA). It will support longitudinal studies of mucosal and microbial phenotypes prior to RA onset, focusing on autoimmunity development and arthritis progression. The research involves identifying immune drivers, characterizing B and T cell responses to mucosal bacteria, and investigating molecular mimicry and epitope spreading mechanisms that contribute to RA. The study leverages unique longitudinal data and biological samples from a highly collaborative, multi-institutional group.