Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK139244-03
Dysregulation of calcium signaling in the initiation of fatty liver disease
Recipient
Rutgers Biomedical and Health Sciences
Award Amount
$526,782.00
Ceiling
$526,782.00
Awarded
May 21, 2026
Identifier
5R01DK139244-03
Research project funded by NIH to study how high fat diet affects calcium signaling in the liver, contributing to fatty liver disease and metabolic disorders.
Description
This project aims to elucidate the early changes in calcium signaling in response to high fat diet, which may precipitate maladaptations in hormonal regulation of hepatic metabolism resulting in liver disease, diabetes, and related comorbidities. It investigates molecular mechanisms by which high fat diet suppresses calcium signaling, zonal differences in calcium signaling affected by diet, and how these changes promote lipogenesis and metabolic dysregulation in the liver.