Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R56DK141457-01A1
Structural Proteome Diversity as a Determinant of Hematopoietic Aging
Recipient
Baylor College of Medicine
Award Amount
$200,000.00
Ceiling
$200,000.00
Awarded
September 02, 2025
Identifier
1R56DK141457-01A1
The award funds research to quantitatively map how proteostatic stress affects hematopoietic stem cell fate, using advanced molecular analyses to inform strategies for stem cell maintenance and therapeutic interventions.
Description
This project addresses how proteostatic stress influences fate decisions in hematopoietic stem cells (HSCs) by integrating controlled perturbations of protein quality control pathways with phenotypic, transcriptomic, and proteomic analyses. It aims to map proteostatic and metabolic stressors' effects on murine and human HSC populations to identify conserved stress-response programs and actionable proteostatic modules.