Award
National Institute of Neurological Disorders and Stroke 5R01NS102617-09
A Novel Wavelet Neurovascular Bundle for Real Time Detection of Injury in Neonatal Encephalopathy
Recipient
UT Southwestern Medical Center, Dallas, TX
Award Amount
$520,441.00
Ceiling
$520,441.00
Awarded
March 30, 2026
Identifier
5R01NS102617-09
NIH funded research project to develop real-time biomarkers for detecting mild neonatal brain injury using advanced neurovascular analysis, aiming to improve early diagnosis and treatment of mild hypoxic-ischemic encephalopathy.
Description
This project aims to develop physiological biomarkers to identify mild hypoxic-ischemic encephalopathy (HIE) infants who need treatment, using a wavelet neurovascular bundle analytical system to measure neurovascular coupling and regional oxygen consumption in real time. The study will enroll 100 neonates with mild HIE, following them for two years to assess developmental outcomes. The infrastructure includes a multidisciplinary team and advanced imaging facilities at Parkland Hospital. Expected outcomes include the development of neuroimaging and neurophysiological assessments for mild HIE and improved stratification via multi-modal assessments, potentially leading to a paradigm shift in early detection and targeted intervention for mild HIE.