Award
National Institute of General Medical Sciences 5R35GM156389-02
Structure and function of phospholipids and inositol phosphates in the nucleus.
Recipient
Vanderbilt University Medical Center
Award Amount
$656,250.00
Ceiling
$656,250.00
Awarded
February 18, 2026
Identifier
5R35GM156389-02
This award funds research to understand the structure and function of nuclear phospholipids and inositol phosphates, develop chemical tools to study them, and explore their role in gene regulation and disease.
Description
Phospholipids and inositol phosphates are two classes of small molecules with well-known functions in the cytoplasm, but poorly defined roles in the nucleus. The goal of the research is to understand the structural biology and functional genomics of these molecules and develop new small molecules to interrogate nuclear lipid functions. The study focuses on nuclear phospholipids and inositol phosphates, their metabolic enzymes, and their role in gene regulation, with potential impacts on cancer, diabetes, and metabolic side effects of antipsychotic drugs.