Award
NIH Reporter #1R56HL164328-01A1
Mechanisms of right ventricular dysfunction in type 2 diabetes
Recipient
University of Wyoming, Laramie, WY, United States
Award Amount
$323,277.00
Ceiling
$323,277.00
Awarded
September 25, 2024
Identifier
1R56HL164328-01A1
Research project funded by the National Heart Lung and Blood Institute to study mechanisms of right ventricular dysfunction in type 2 diabetes, focusing on lipotoxicity and oxidative stress to develop targeted therapies.
Description
This project aims to identify right ventricular-specific mechanisms of diabetic myopathy by studying how fatty acid uptake contributes to right ventricular lipotoxicity and dysfunction, and to identify mechanisms of impaired reactive oxygen species signaling in the diabetic right ventricle. The study aims to demonstrate that right ventricular dysfunction involves lipotoxicity and oxidative stress, which are critical for developing targeted therapies.