Award
National Institute of Dental and Craniofacial Research 5R01DE029211-05
Essential role of amelogenin phosphorylation in tooth enamel formation
Recipient
University of Pittsburgh at Pittsburgh
Award Amount
$446,443.00
Ceiling
$446,443.00
Awarded
August 21, 2024
Identifier
5R01DE029211-05
The study aims to elucidate the role of amelogenin phosphorylation in enamel mineralization using novel mouse models. It builds on findings that phosphorylation at S-16 is critical for enamel structure, with mutant mice showing distinct phenotypes. The research will explore how phosphorylation influences enamel crystal growth, ameloblast function, and protein interactions, ultimately aiding understanding of inherited enamel diseases and caries susceptibility.
Description
This project investigates the phosphorylation of amelogenin and its impact on enamel formation, using a knock-in mouse model with a S16 to alanine mutation. The study aims to understand how phosphorylation affects enamel crystal organization, ameloblast function, and protein interactions, providing insights into inherited enamel disorders and caries risk.